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Induced Dimerization of the Amyloid Precursor Protein Leads to Decreased Amyloid-β Protein Production

The amyloid precursor protein (APP) plays a central role in Alzheimer disease (AD) pathogenesis because sequential cleavages by β- and γ-secretase lead to the generation of the amyloid-β (Aβ) peptide, a key constituent in the amyloid plaques present in brains of AD individuals. In several studies AP...

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Detaylı Bibliyografya
Asıl Yazarlar: Eggert, Simone, Midthune, Brea, Cottrell, Barbara, Koo, Edward H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781440/
https://ncbi.nlm.nih.gov/pubmed/19596858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038646
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