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Induced Dimerization of the Amyloid Precursor Protein Leads to Decreased Amyloid-β Protein Production
The amyloid precursor protein (APP) plays a central role in Alzheimer disease (AD) pathogenesis because sequential cleavages by β- and γ-secretase lead to the generation of the amyloid-β (Aβ) peptide, a key constituent in the amyloid plaques present in brains of AD individuals. In several studies AP...
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| Asıl Yazarlar: | , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Biochemistry and Molecular Biology
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2781440/ https://ncbi.nlm.nih.gov/pubmed/19596858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038646 |
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