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The amyloid precursor protein: beyond amyloid

The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and duplications of APP are causal for a subset of...

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Bibliographic Details
Main Authors: Zheng, Hui, Koo, Edward H
Format: Artigo
Language:Inglês
Published: BioMed Central 2006
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1538601/
https://ncbi.nlm.nih.gov/pubmed/16930452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-1-5
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