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Benzenesulfonamides: A Unique Class of Chemokine Receptor Type 4 Inhibitors
The interaction of CXCR4 with CXCL12 (SDF-1) plays a critical role in cancer metastasis by facilitating the homing of tumor cells to metastatic sites. Based on our previously published work on CXCR4 antagonists, we have synthesized a series of aryl sulfonamides that inhibit the CXCR4/CXCL12 interact...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3752296/ https://ncbi.nlm.nih.gov/pubmed/23468189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201200582 |
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