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Dipyrimidine Amines: A Novel Class of Chemokine Receptor Type 4 Antagonists with High Specificity
The C-X-C chemokine receptor type 4 (CXCR4)/stromal cell derived factor-1 (SDF-1 or CXCL12) interaction and the resulting cell signaling cascade play a key role in metastasis and inflammation. Based on the previously published CXCR4 antagonist 5 (WZ811), a series of novel non-peptidic anti-CXCR4 sma...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3003753/ https://ncbi.nlm.nih.gov/pubmed/21105715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100786g |
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