Dipyrimidine Amines: A Novel Class of Chemokine Receptor Type 4 Antagonists with High Specificity

The C-X-C chemokine receptor type 4 (CXCR4)/stromal cell derived factor-1 (SDF-1 or CXCL12) interaction and the resulting cell signaling cascade play a key role in metastasis and inflammation. Based on the previously published CXCR4 antagonist 5 (WZ811), a series of novel non-peptidic anti-CXCR4 sma...

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Hlavní autoři: Zhu, Aizhi, Zhan, Weiqiang, Liang, Zhongxing, Yoon, Younghyoun, Yang, Hua, Grossniklaus, Hans E., Xu, Jianguo, Rojas, Mauricio, Lockwood, Mark, Snyder, James P., Liotta, Dennis C., Shim, Hyunsuk
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003753/
https://ncbi.nlm.nih.gov/pubmed/21105715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100786g
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