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Benzenesulfonamides: A Unique Class of Chemokine Receptor Type 4 Inhibitors

The interaction of CXCR4 with CXCL12 (SDF-1) plays a critical role in cancer metastasis by facilitating the homing of tumor cells to metastatic sites. Based on our previously published work on CXCR4 antagonists, we have synthesized a series of aryl sulfonamides that inhibit the CXCR4/CXCL12 interact...

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Detalhes bibliográficos
Main Authors: Mooring, Suazette Reid, Liu, Jin, Liang, Zhongxing, Ahn, Jeffrey, Hong, Samuel, Yoon, Younghyoun, Snyder, James P., Shim, Hyunsuk
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752296/
https://ncbi.nlm.nih.gov/pubmed/23468189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201200582
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