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Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme
Insulin-degrading enzyme (IDE) selectively degrades the monomer of amyloidogenic peptides and contributes to clearance of amyloid β (Aβ). Thus, IDE retards the progression of Alzheimer’s disease. IDE possesses an enclosed catalytic chamber that engulfs and degrades its peptide substrates; however, t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3752249/ https://ncbi.nlm.nih.gov/pubmed/23922390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304575110 |
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