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Degradation of Alzheimer’s amyloid-β by a catalytically inactive insulin-degrading enzyme
It is known that insulin-degrading-enzyme (IDE) plays a crucial role in the clearance of Alzheimer’s amyloid-β (Aβ). The cysteine-free IDE mutant (cf-E111Q-IDE) is catalytically inactive against insulin, but its effect on Aβ degradation is unknown that would help in the allosteric modulation of the...
Shranjeno v:
| izdano v: | J Mol Biol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2021
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8169600/ https://ncbi.nlm.nih.gov/pubmed/33865867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2021.166993 |
| Oznake: |
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