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Degradation of Alzheimer’s amyloid-β by a catalytically inactive insulin-degrading enzyme

It is known that insulin-degrading-enzyme (IDE) plays a crucial role in the clearance of Alzheimer’s amyloid-β (Aβ). The cysteine-free IDE mutant (cf-E111Q-IDE) is catalytically inactive against insulin, but its effect on Aβ degradation is unknown that would help in the allosteric modulation of the...

詳細記述

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書誌詳細
出版年:J Mol Biol
主要な著者: Sahoo, Bikash R., Panda, Pritam Kumar, Liang, Wenguang, Tang, Wei-Jen, Ahuja, Rajeev, Ramamoorthy, Ayyalusamy
フォーマット: Artigo
言語:Inglês
出版事項: 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169600/
https://ncbi.nlm.nih.gov/pubmed/33865867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2021.166993
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