Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

Insulin-degrading enzyme (IDE) selectively degrades the monomer of amyloidogenic peptides and contributes to clearance of amyloid β (Aβ). Thus, IDE retards the progression of Alzheimer’s disease. IDE possesses an enclosed catalytic chamber that engulfs and degrades its peptide substrates; however, t...

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Bibliografski detalji
Glavni autori: McCord, Lauren A., Liang, Wenguang G., Dowdell, Evan, Kalas, Vasilios, Hoey, Robert J., Koide, Akiko, Koide, Shohei, Tang, Wei-Jen
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752249/
https://ncbi.nlm.nih.gov/pubmed/23922390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304575110
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