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Ubiquitin is a Novel Substrate for Human Insulin-Degrading Enzyme
Insulin-degrading enzyme (IDE) can degrade insulin and amyloid-β (Aβ), peptides involved in diabetes and Alzheimer's disease, respectively. IDE selects its substrates based on size, charge, and flexibility. From these criteria, we predict that IDE can cleave and inactivate ubiquitin (Ub). Here,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3064465/ https://ncbi.nlm.nih.gov/pubmed/21185309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.12.026 |
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