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Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme
Insulin degrading enzyme (IDE) utilizes a large catalytic chamber to selectively bind and degrade peptide substrates such as insulin and amyloid β (Aβ). Tight interactions with substrates occur at an exosite located ~30Å away from the catalytic center that anchors the N-terminus of substrates to fac...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2652632/ https://ncbi.nlm.nih.gov/pubmed/18986166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801192h |
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