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Molecular basis for the recognition and cleavages of IGF-II, TGF-α, and amylin by human insulin degrading enzyme
Insulin-degrading enzyme (IDE) is involved in the clearance of many bioactive peptide substrates, including insulin and amyloid-β (Aβ), peptides vital to the development of diabetes and Alzheimer's disease, respectively. IDE can also rapidly degrade hormones that are held together by intra-mole...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2813390/ https://ncbi.nlm.nih.gov/pubmed/19896952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.10.072 |
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