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Molecular basis for the thiol sensitivity of insulin-degrading enzyme
Insulin-degrading enzyme (IDE) is a ubiquitous zinc-metalloprotease that hydrolyzes several pathophysiologically relevant peptides, including insulin and the amyloid β-protein (Aβ). IDE is inhibited irreversibly by compounds that covalently modify cysteine residues, a mechanism that could be operati...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2474492/ https://ncbi.nlm.nih.gov/pubmed/18621727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801261105 |
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