Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening

BACKGROUND: Hypocatabolism of the amyloid β-protein (Aβ) by insulin-degrading enzyme (IDE) is implicated in the pathogenesis of Alzheimer disease (AD), making pharmacological activation of IDE an attractive therapeutic strategy. However, it has not been established whether the proteolytic activity o...

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Détails bibliographiques
Auteurs principaux: Cabrol, Christelle, Huzarska, Malwina A., Dinolfo, Christopher, Rodriguez, Maria C., Reinstatler, Lael, Ni, Jake, Yeh, Li-An, Cuny, Gregory D., Stein, Ross L., Selkoe, Dennis J., Leissring, Malcolm A.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2009
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668070/
https://ncbi.nlm.nih.gov/pubmed/19384407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005274
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