Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening

BACKGROUND: Hypocatabolism of the amyloid β-protein (Aβ) by insulin-degrading enzyme (IDE) is implicated in the pathogenesis of Alzheimer disease (AD), making pharmacological activation of IDE an attractive therapeutic strategy. However, it has not been established whether the proteolytic activity o...

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Detalhes bibliográficos
Main Authors: Cabrol, Christelle, Huzarska, Malwina A., Dinolfo, Christopher, Rodriguez, Maria C., Reinstatler, Lael, Ni, Jake, Yeh, Li-An, Cuny, Gregory D., Stein, Ross L., Selkoe, Dennis J., Leissring, Malcolm A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668070/
https://ncbi.nlm.nih.gov/pubmed/19384407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005274
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