Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin

BACKGROUND: Insulin is a vital peptide hormone that is a central regulator of glucose homeostasis, and impairments in insulin signaling cause diabetes mellitus. In principle, it should be possible to enhance the activity of insulin by inhibiting its catabolism, which is mediated primarily by insulin...

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Hauptverfasser: Leissring, Malcolm A., Malito, Enrico, Hedouin, Sabrine, Reinstatler, Lael, Sahara, Tomoko, Abdul-Hay, Samer O., Choudhry, Shakeel, Maharvi, Ghulam M., Fauq, Abdul H., Huzarska, Malwina, May, Philip S., Choi, Sungwoon, Logan, Todd P., Turk, Benjamin E., Cantley, Lewis C., Manolopoulou, Marika, Tang, Wei-Jen, Stein, Ross L., Cuny, Gregory D., Selkoe, Dennis J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866327/
https://ncbi.nlm.nih.gov/pubmed/20498699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010504
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