Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme

BACKGROUND: Insulin-degrading enzyme (IDE) is a widely studied zinc-metalloprotease implicated in the pathogenesis of type 2 diabetes mellitus, Alzheimer disease (AD) and varicella zoster virus infection. Despite more than six decades of research on IDE, progress has been hampered by the lack of wel...

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Autors principals: DelleDonne, Anthony, Kouri, Naomi, Reinstatler, Lael, Sahara, Tomoko, Li, Lilin, Zhao, Ji, Dickson, Dennis W, Ertekin-Taner, Nilufer, Leissring, Malcolm A
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
Matèries:
Methodology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768702/
https://ncbi.nlm.nih.gov/pubmed/19835587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-4-39
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