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Identification of BACE2 as an avid ß-amyloid-degrading protease

BACKGROUND: Proteases that degrade the amyloid ß-protein (Aß) have emerged as key players in the etiology and potential treatment of Alzheimer’s disease (AD), but it is unlikely that all such proteases have been identified. To discover new Aß-degrading proteases (AßDPs), we conducted an unbiased, ge...

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מידע ביבליוגרפי
Main Authors: Abdul-Hay, Samer O, Sahara, Tomoko, McBride, Melinda, Kang, Dongcheul, Leissring, Malcolm A
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470943/
https://ncbi.nlm.nih.gov/pubmed/22986058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-46
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