Identification of BACE2 as an avid ß-amyloid-degrading protease

BACKGROUND: Proteases that degrade the amyloid ß-protein (Aß) have emerged as key players in the etiology and potential treatment of Alzheimer’s disease (AD), but it is unlikely that all such proteases have been identified. To discover new Aß-degrading proteases (AßDPs), we conducted an unbiased, ge...

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Main Authors: Abdul-Hay, Samer O, Sahara, Tomoko, McBride, Melinda, Kang, Dongcheul, Leissring, Malcolm A
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470943/
https://ncbi.nlm.nih.gov/pubmed/22986058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-46
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