Identification of BACE2 as an avid ß-amyloid-degrading protease

BACKGROUND: Proteases that degrade the amyloid ß-protein (Aß) have emerged as key players in the etiology and potential treatment of Alzheimer’s disease (AD), but it is unlikely that all such proteases have been identified. To discover new Aß-degrading proteases (AßDPs), we conducted an unbiased, ge...

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Bibliographic Details
Main Authors: Abdul-Hay, Samer O, Sahara, Tomoko, McBride, Melinda, Kang, Dongcheul, Leissring, Malcolm A
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470943/
https://ncbi.nlm.nih.gov/pubmed/22986058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-46
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