Molecular basis for the thiol sensitivity of insulin-degrading enzyme

Insulin-degrading enzyme (IDE) is a ubiquitous zinc-metalloprotease that hydrolyzes several pathophysiologically relevant peptides, including insulin and the amyloid β-protein (Aβ). IDE is inhibited irreversibly by compounds that covalently modify cysteine residues, a mechanism that could be operati...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Neant-Fery, Marie, Garcia-Ordoñez, Rubén D., Logan, Todd P., Selkoe, Dennis J., Li, Lilin, Reinstatler, Lael, Leissring, Malcolm A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2008
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474492/
https://ncbi.nlm.nih.gov/pubmed/18621727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801261105
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