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Molecular basis for the recognition and cleavages of IGF-II, TGF-α, and amylin by human insulin degrading enzyme

Insulin-degrading enzyme (IDE) is involved in the clearance of many bioactive peptide substrates, including insulin and amyloid-β (Aβ), peptides vital to the development of diabetes and Alzheimer's disease, respectively. IDE can also rapidly degrade hormones that are held together by intra-mole...

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Detalhes bibliográficos
Main Authors: Guo, Qing, Manolopoulou, Marika, Bian, Yao, Schilling, Alexander B., Tang, Wei-Jen
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813390/
https://ncbi.nlm.nih.gov/pubmed/19896952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.10.072
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