R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation

Prader–Willi syndrome (PWS) and Angelman syndrome (AS) are oppositely imprinted autism-spectrum disorders with known genetic bases, but complex epigenetic mechanisms underlie their pathogenesis. The PWS/AS locus on 15q11–q13 is regulated by an imprinting control region that is maternally methylated...

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Hlavní autoři: Powell, Weston T., Coulson, Rochelle L., Gonzales, Michael L., Crary, Florence K., Wong, Spencer S., Adams, Sarrita, Ach, Robert A., Tsang, Peter, Yamada, Nazumi Alice, Yasui, Dag H., Chédin, Frédéric, LaSalle, Janine M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752217/
https://ncbi.nlm.nih.gov/pubmed/23918391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305426110
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