R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation

Prader–Willi syndrome (PWS) and Angelman syndrome (AS) are oppositely imprinted autism-spectrum disorders with known genetic bases, but complex epigenetic mechanisms underlie their pathogenesis. The PWS/AS locus on 15q11–q13 is regulated by an imprinting control region that is maternally methylated...

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Détails bibliographiques
Auteurs principaux: Powell, Weston T., Coulson, Rochelle L., Gonzales, Michael L., Crary, Florence K., Wong, Spencer S., Adams, Sarrita, Ach, Robert A., Tsang, Peter, Yamada, Nazumi Alice, Yasui, Dag H., Chédin, Frédéric, LaSalle, Janine M.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2013
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752217/
https://ncbi.nlm.nih.gov/pubmed/23918391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305426110
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