Heterodimerization with Its Splice Variant Blocks the Ghrelin Receptor 1a in a Non-signaling Conformation: A STUDY WITH A PURIFIED HETERODIMER ASSEMBLED INTO LIPID DISCS

Heterodimerization of G protein-coupled receptors has an impact on their signaling properties, but the molecular mechanisms underlying heteromer-directed selectivity remain elusive. Using purified monomers and dimers reconstituted into lipid discs, we explored how dimerization impacts the functional...

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Главные авторы: Mary, Sophie, Fehrentz, Jean-Alain, Damian, Marjorie, Gaibelet, Gérald, Orcel, Hélène, Verdié, Pascal, Mouillac, Bernard, Martinez, Jean, Marie, Jacky, Banères, Jean-Louis
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2013
Предметы:
Signal Transduction
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750163/
https://ncbi.nlm.nih.gov/pubmed/23839942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.453423
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