Combination of mTOR and EGFR Kinase Inhibitors Blocks mTORC1 and mTORC2 Kinase Activity and Suppresses the Progression of Colorectal Carcinoma

Mammalian target of rapamycin complex 1 and 2 (mTORC1/2) are overactive in colorectal carcinomas; however, the first generation of mTOR inhibitors such as rapamycin have failed to show clinical benefits in treating colorectal carcinoma in part due to their effects only on mTORC1. The second generati...

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Bibliographic Details
Main Authors: Wang, Quan, Wei, Feng, Li, Chunsheng, Lv, Guoyue, Wang, Guangyi, Liu, Tongjun, Bellail, Anita C., Hao, Chunhai
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750018/
https://ncbi.nlm.nih.gov/pubmed/23991179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073175
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