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mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition
The mammalian target of rapamycin (mTOR) is a kinase that functions in two distinct complexes, mTORC1 and mTORC2. In peripheral B cells, complete deletion of mTOR suppresses germinal center B-cell responses, including class switching and somatic hypermutation. The allosteric mTORC1 inhibitor rapamyc...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4250172/ https://ncbi.nlm.nih.gov/pubmed/25385646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407104111 |
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