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Combination of mTOR and EGFR Kinase Inhibitors Blocks mTORC1 and mTORC2 Kinase Activity and Suppresses the Progression of Colorectal Carcinoma

Mammalian target of rapamycin complex 1 and 2 (mTORC1/2) are overactive in colorectal carcinomas; however, the first generation of mTOR inhibitors such as rapamycin have failed to show clinical benefits in treating colorectal carcinoma in part due to their effects only on mTORC1. The second generati...

詳細記述

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書誌詳細
主要な著者: Wang, Quan, Wei, Feng, Li, Chunsheng, Lv, Guoyue, Wang, Guangyi, Liu, Tongjun, Bellail, Anita C., Hao, Chunhai
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750018/
https://ncbi.nlm.nih.gov/pubmed/23991179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073175
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