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Combination of mTOR and EGFR Kinase Inhibitors Blocks mTORC1 and mTORC2 Kinase Activity and Suppresses the Progression of Colorectal Carcinoma

Mammalian target of rapamycin complex 1 and 2 (mTORC1/2) are overactive in colorectal carcinomas; however, the first generation of mTOR inhibitors such as rapamycin have failed to show clinical benefits in treating colorectal carcinoma in part due to their effects only on mTORC1. The second generati...

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Autors principals: Wang, Quan, Wei, Feng, Li, Chunsheng, Lv, Guoyue, Wang, Guangyi, Liu, Tongjun, Bellail, Anita C., Hao, Chunhai
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750018/
https://ncbi.nlm.nih.gov/pubmed/23991179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073175
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