mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity

The mammalian target of rapamycin (mTOR), present in mTOR complex 1 (mTORC1) and mTORC2, is a serine/threonine kinase that integrates nutrients, growth factors, and cellular energy status to control protein synthesis, cell growth, survival and metabolism. However, it remains elusive whether mTOR pla...

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Udgivet i:PLoS One
Main Authors: Kalim, Khalid W., Zhang, Shuangmin, Chen, Xiaoyi, Li, Yuan, Yang, Jun-Qi, Zheng, Yi, Guo, Fukun
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558967/
https://ncbi.nlm.nih.gov/pubmed/28813526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183266
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