BSTA Promotes mTORC2-Mediated Phosphorylation of Akt1 to Suppress Expression of FoxC2 and Stimulate Adipocyte Differentiation

Phosphorylation and activation of Akt1 is a crucial signaling event that promotes adipogenesis. However, neither the complex multistep process that leads to activation of Akt1 through phosphorylation at Thr(308) and Ser(473) nor the mechanism by which Akt1 stimulates adipogenesis is fully understood...

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Main Authors: Yao, Yixin, Suraokar, Milind, Darnay, Bryant G., Hollier, Brett G., Shaiken, Tattym E., Asano, Takayuki, Chen, Chien-Hung, Chang, Benny H.-J., Lu, Yiling, Mills, Gordon B., Sarbassov, Dos, Mani, Sendurai A., Abbruzzese, James L., Reddy, Shrikanth A. G.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748614/
https://ncbi.nlm.nih.gov/pubmed/23300339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003295
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