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Force and kinetic barriers to unzipping of the DNA double helix

A theory of the unzipping of double-stranded DNA is presented and is compared to recent micromanipulation experiments. It is shown that the interactions that stabilize the double helix and the elastic rigidity of single strands simply determine the sequence-dependent ≈12-pN force threshold for DNA s...

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Autores principales: Cocco, Simona, Monasson, Rémi, Marko, John F.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2001
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC37483/
https://ncbi.nlm.nih.gov/pubmed/11447279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.151257598
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