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Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

Base oxidation by endogenous and environmentally induced reactive oxygen species preferentially occurs in replicating single-stranded templates in mammalian genomes, warranting prereplicative repair of the mutagenic base lesions. It is not clear how such lesions (which, unlike bulky adducts, do not...

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Bibliografiske detaljer
Main Authors: Hegde, Muralidhar L., Hegde, Pavana M., Bellot, Larry J., Mandal, Santi M., Hazra, Tapas K., Li, Guo-Min, Boldogh, Istvan, Tomkinson, Alan E., Mitra, Sankar
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746843/
https://ncbi.nlm.nih.gov/pubmed/23898192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304231110
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