Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II

Promoter-proximal pausing by RNA polymerase II (Pol II) ensures both gene-specific regulation and RNA quality control. Structural considerations suggested initiation factor eviction would be required for elongation factor engagement and pausing of transcription complexes. Here we show that selective...

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Hauptverfasser: Larochelle, Stéphane, Amat, Ramon, Glover-Cutter, Kira, Sansó, Miriam, Zhang, Chao, Allen, Jasmina J., Shokat, Kevan M., Bentley, David L., Fisher, Robert P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746743/
https://ncbi.nlm.nih.gov/pubmed/23064645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2399
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