Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency

Cellular stress or injury can result in mitochondrial dysfunction, which has been linked to many chronic neurological disorders including amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). Stressed and dysfunctional mitochondria exhibit an increase in large conductance mitochondrial m...

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Main Authors: Alavian, Kambiz N., Dworetzky, Steven I., Bonanni, Laura, Zhang, Ping, Sacchetti, Silvio, Mariggio, Maria A., Onofrj, Marco, Thomas, Astrid, Li, Hongmei, Mangold, Jamie E., Signore, Armando P., DeMarco, Ulrike, Demady, Damon R., Nabili, Panah, Lazrove, Emma, Smith, Peter J.S., Gribkoff, Valentin K., Jonas, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746080/
https://ncbi.nlm.nih.gov/pubmed/22364637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2012.01.046
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