An uncoupling channel within the c-subunit ring of the F(1)F(O) ATP synthase is the mitochondrial permeability transition pore

Mitochondria maintain tight regulation of inner mitochondrial membrane (IMM) permeability to sustain ATP production. Stressful events cause cellular calcium (Ca(2+)) dysregulation followed by rapid loss of IMM potential known as permeability transition (PT), which produces osmotic shifts, metabolic...

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Detalhes bibliográficos
Main Authors: Alavian, Kambiz N., Beutner, Gisela, Lazrove, Emma, Sacchetti, Silvio, Park, Han-A, Licznerski, Pawel, Li, Hongmei, Nabili, Panah, Hockensmith, Kathryn, Graham, Morven, Porter, George A., Jonas, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115574/
https://ncbi.nlm.nih.gov/pubmed/24979777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401591111
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