An uncoupling channel within the c-subunit ring of the F(1)F(O) ATP synthase is the mitochondrial permeability transition pore

Mitochondria maintain tight regulation of inner mitochondrial membrane (IMM) permeability to sustain ATP production. Stressful events cause cellular calcium (Ca(2+)) dysregulation followed by rapid loss of IMM potential known as permeability transition (PT), which produces osmotic shifts, metabolic...

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Hauptverfasser: Alavian, Kambiz N., Beutner, Gisela, Lazrove, Emma, Sacchetti, Silvio, Park, Han-A, Licznerski, Pawel, Li, Hongmei, Nabili, Panah, Hockensmith, Kathryn, Graham, Morven, Porter, George A., Jonas, Elizabeth A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115574/
https://ncbi.nlm.nih.gov/pubmed/24979777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401591111
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