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Bcl-x(L) regulates metabolic efficiency of neurons through interaction with the mitochondrial F(1)F(O) ATP synthase

Anti-apoptotic Bcl2 family proteins such as Bcl-x(L) protect cells from death by sequestering apoptotic molecules, but also contribute to normal neuronal function. We find in hippocampal neurons that Bcl-x(L) enhances the efficiency of energy metabolism. Our evidence suggests that Bcl-x(L) interacts...

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Detalhes bibliográficos
Main Authors: Alavian, Kambiz N., Li, Hongmei, Collis, Leon, Bonanni, Laura, Zeng, Lu, Sacchetti, Silvio, Lazrove, Emma, Nabili, Panah, Flaherty, Benjamin, Graham, Morven, Chen, Yingbei, Messerli, Shanta, Mariggio, Maria A., Rahner, Christoph, McNay, Ewan, Shore, Gordon, Smith, Peter J. S., Hardwick, J. Marie, Jonas, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186867/
https://ncbi.nlm.nih.gov/pubmed/21926988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2330
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