N-terminally cleaved Bcl-x(L) mediates ischemia-induced neuronal death

Transient global ischemia in rats induces delayed death of hippocampal CA1 neurons. Early events include caspase activation, cleavage of anti-death Bcl-2 family proteins and large mitochondrial channel activity. However, a causal role of these events in ischemia-induced neuronal death is unclear. Un...

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Hauptverfasser: Ofengeim, Dimitry, Chen, Yingbei, Miyawaki, Takahiro, Li, Hongmei, Sacchetti, Silvio, Flannery, Richard J., Alavian, Kambiz N., Pontarelli, Fabrizio, Roelofs, Brian A., Hickman, John A., Hardwick, J. Marie, Zukin, R. Suzanne, Jonas, Elizabeth A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3862259/
https://ncbi.nlm.nih.gov/pubmed/22366758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3054
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