Ischemic preconditioning blocks BAD translocation, Bcl-x(L) cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons

Transient forebrain or global ischemia induces delayed neuronal death in vulnerable CA1 pyramidal cells with many features of apoptosis. A brief period of ischemia, i.e., ischemic preconditioning, affords robust protection of CA1 neurons against a subsequent more prolonged ischemic challenge. Here w...

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Detalhes bibliográficos
Main Authors: Miyawaki, Takahiro, Mashiko, Toshihiro, Ofengeim, Dimitry, Flannery, Richard J., Noh, Kyung-Min, Fujisawa, Sho, Bonanni, Laura, Bennett, Michael V. L., Zukin, R. Suzanne, Jonas, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290755/
https://ncbi.nlm.nih.gov/pubmed/18347331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800628105
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