Dexpramipexole improves bioenergetics and outcome in experimental stroke

BACKGROUND AND PURPOSE: Dexpramipexole, a drug recently tested in patients with amyotrophic lateral sclerosis (ALS,) is able to bind F1Fo ATP synthase and increase mitochondrial ATP production. Here, we have investigated its effects on experimental ischaemic brain injury. EXPERIMENTAL APPROACH: The...

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Bibliografske podrobnosti
izdano v:Br J Pharmacol
Main Authors: Muzzi, Mirko, Gerace, Elisabetta, Buonvicino, Daniela, Coppi, Elisabetta, Resta, Francesco, Formentini, Laura, Zecchi, Riccardo, Tigli, Laura, Guasti, Daniele, Ferri, Martina, Camaioni, Emidio, Masi, Alessio, Pellegrini‐Giampietro, Domenico E, Mannaioni, Guido, Bani, Daniele, Pugliese, Anna M, Chiarugi, Alberto
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Themed Section: Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758384/
https://ncbi.nlm.nih.gov/pubmed/28320070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13790
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