Dual Farnesoid X Receptor/TGR5 Agonist INT-767 Reduces Liver Injury in the Mdr2(−/−) (Abcb4(−/−)) Mouse Cholangiopathy Model by Promoting Biliary [Formula: see text] Output

Chronic cholangiopathies have limited therapeutic options and represent an important indication for liver transplantation. The nuclear farnesoid X receptor (FXR) and the membrane G protein-coupled receptor, TGR5, regulate bile acid (BA) homeostasis and inflammation. Therefore, we hypothesized that a...

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Autors principals: Baghdasaryan, Anna, Claudel, Thierry, Gumhold, Judith, Silbert, Dagmar, Adorini, Luciano, Roda, Aldo, Vecchiotti, Stefania, Gonzalez, Frank J., Schoonjans, Kristina, Strazzabosco, Mario, Fickert, Peter, Trauner, Michael
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744065/
https://ncbi.nlm.nih.gov/pubmed/22006858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24537
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