An Unbiased Approach to Identifying Tau Kinases That Phosphorylate Tau at Sites Associated with Alzheimer Disease

Neurofibrillary tangles, one of the hallmarks of Alzheimer disease (AD), are composed of paired helical filaments of abnormally hyperphosphorylated tau. The accumulation of these proteinaceous aggregates in AD correlates with synaptic loss and severity of dementia. Identifying the kinases involved i...

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Bibliographische Detailangaben
Hauptverfasser: Cavallini, Annalisa, Brewerton, Suzanne, Bell, Amanda, Sargent, Samantha, Glover, Sarah, Hardy, Clare, Moore, Roger, Calley, John, Ramachandran, Devaki, Poidinger, Michael, Karran, Eric, Davies, Peter, Hutton, Michael, Szekeres, Philip, Bose, Suchira
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743503/
https://ncbi.nlm.nih.gov/pubmed/23798682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.463984
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