Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau

The interneuronal propagation of aggregated tau is believed to play an important role in the pathogenesis of human tauopathies. It requires the uptake of seed-competent tau into cells, seeding of soluble tau in recipient neurons and release of seeded tau into the extracellular space to complete the...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Jackson, Samuel J., Kerridge, Caroline, Cooper, Jane, Cavallini, Annalisa, Falcon, Benjamin, Cella, Claire V., Landi, Alessia, Szekeres, Philip G., Murray, Tracey K., Ahmed, Zeshan, Goedert, Michel, Hutton, Michael, O'Neill, Michael J., Bose, Suchira
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719013/
https://ncbi.nlm.nih.gov/pubmed/26791207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3542-15.2016
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