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Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network
Tauopathies are a diverse class of neurodegenerative diseases characterized by the formation of insoluble tau aggregates and the loss of cellular function and neuronal death. Tau inclusions have been shown to contain a number of proteins, including molecular chaperones, but the consequences of these...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6514629/ https://ncbi.nlm.nih.gov/pubmed/30936201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007527 |
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