Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen

Despite presence of circulating retina-specific T cells in healthy individuals, ocular immune privilege usually averts development of autoimmune uveitis. To study the breakdown of immune privilege and development of disease, we generated transgenic (Tg) mice that express a T cell receptor (TCR) spec...

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Autori principali: Horai, Reiko, Silver, Phyllis B., Chen, Jun, Agarwal, Rajeev K., Chong, Wai Po, Jittayasothorn, Yingyos, Mattapallil, Mary J., Nguyen, Sonia, Natarajan, Kannan, Villasmil, Rafael, Wang, Peng, Karabekian, Zaruhi, Lytton, Simon D., Chan, Chi-Chao, Caspi, Rachel R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743101/
https://ncbi.nlm.nih.gov/pubmed/23810578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2013.06.003
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