Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen

Despite presence of circulating retina-specific T cells in healthy individuals, ocular immune privilege usually averts development of autoimmune uveitis. To study the breakdown of immune privilege and development of disease, we generated transgenic (Tg) mice that express a T cell receptor (TCR) spec...

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Autors principals: Horai, Reiko, Silver, Phyllis B., Chen, Jun, Agarwal, Rajeev K., Chong, Wai Po, Jittayasothorn, Yingyos, Mattapallil, Mary J., Nguyen, Sonia, Natarajan, Kannan, Villasmil, Rafael, Wang, Peng, Karabekian, Zaruhi, Lytton, Simon D., Chan, Chi-Chao, Caspi, Rachel R.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743101/
https://ncbi.nlm.nih.gov/pubmed/23810578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2013.06.003
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