Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen

Despite presence of circulating retina-specific T cells in healthy individuals, ocular immune privilege usually averts development of autoimmune uveitis. To study the breakdown of immune privilege and development of disease, we generated transgenic (Tg) mice that express a T cell receptor (TCR) spec...

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Hauptverfasser: Horai, Reiko, Silver, Phyllis B., Chen, Jun, Agarwal, Rajeev K., Chong, Wai Po, Jittayasothorn, Yingyos, Mattapallil, Mary J., Nguyen, Sonia, Natarajan, Kannan, Villasmil, Rafael, Wang, Peng, Karabekian, Zaruhi, Lytton, Simon D., Chan, Chi-Chao, Caspi, Rachel R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743101/
https://ncbi.nlm.nih.gov/pubmed/23810578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2013.06.003
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