Capturing the mutational landscape of the beta-lactamase TEM-1

Adaptation proceeds through the selection of mutations. The distribution of mutant fitness effect and the forces shaping this distribution are therefore keys to predict the evolutionary fate of organisms and their constituents such as enzymes. Here, by producing and sequencing a comprehensive collec...

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Detalhes bibliográficos
Main Authors: Jacquier, Hervé, Birgy, André, Le Nagard, Hervé, Mechulam, Yves, Schmitt, Emmanuelle, Glodt, Jérémy, Bercot, Beatrice, Petit, Emmanuelle, Poulain, Julie, Barnaud, Guilène, Gros, Pierre-Alexis, Tenaillon, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740883/
https://ncbi.nlm.nih.gov/pubmed/23878237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215206110
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