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The Evolution of Epistasis and Its Links With Genetic Robustness, Complexity and Drift in a Phenotypic Model of Adaptation

The epistatic interactions among mutations have a large effect on the evolution of populations. In this article we provide a formalism under which epistatic interactions among pairs of mutations have a distribution whose mean can be modulated. We find that the mean epistasis is correlated to the eff...

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Detalhes bibliográficos
Main Authors: Gros, Pierre-Alexis, Le Nagard, Hervé, Tenaillon, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674823/
https://ncbi.nlm.nih.gov/pubmed/19279327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.099127
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