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Capturing the mutational landscape of the beta-lactamase TEM-1
Adaptation proceeds through the selection of mutations. The distribution of mutant fitness effect and the forces shaping this distribution are therefore keys to predict the evolutionary fate of organisms and their constituents such as enzymes. Here, by producing and sequencing a comprehensive collec...
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| Huvudupphovsmän: | , , , , , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2013
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3740883/ https://ncbi.nlm.nih.gov/pubmed/23878237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215206110 |
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