Capturing the mutational landscape of the beta-lactamase TEM-1

Adaptation proceeds through the selection of mutations. The distribution of mutant fitness effect and the forces shaping this distribution are therefore keys to predict the evolutionary fate of organisms and their constituents such as enzymes. Here, by producing and sequencing a comprehensive collec...

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Autori principali: Jacquier, Hervé, Birgy, André, Le Nagard, Hervé, Mechulam, Yves, Schmitt, Emmanuelle, Glodt, Jérémy, Bercot, Beatrice, Petit, Emmanuelle, Poulain, Julie, Barnaud, Guilène, Gros, Pierre-Alexis, Tenaillon, Olivier
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740883/
https://ncbi.nlm.nih.gov/pubmed/23878237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215206110
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